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generic cialis online pharmacy Paradoxically, T type Ca 2 channels are actually known to open during membrane depolarization and thus are expected to mediate Ca 2 influx into cells after an action potential or in response to depolarizing signals, whereas the epithelial Ca 2 channel TRPV6 channels would seem more appropriate to facilitate Ca 2 entry into cancer cells, as they are open at the negative resting potentials of these cells